Pathology and Telepathology Methods in the Child Health and Mortality Prevention Surveillance Network

Submitted by bjibendi on Sun, 02/28/2021 - 01:49

This manuscript describes the Child Health and Mortality Prevention Surveillance (CHAMPS) network approach to pathologic evaluation of minimally invasive tissue sampling (MITS) specimens, including guidelines for histopathologic examination and further diagnostics with special stains, immunohistochemistry, and molecular testing, as performed at the CHAMPS Central Pathology Laboratory (CPL) at the Centers for Disease Control and Prevention, as well as techniques for virtual discussion of these cases (telepathology) with CHAMPS surveillance locations. Based on review of MITS from the early phase of CHAMPS, the CPL has developed standardized histopathology-based algorithms for achieving diagnoses from MITS and telepathology procedures in conjunction with the CHAMPS sites, with the use of whole slide scanners and digital image archives, for maximizing concurrence and knowledge sharing between site and CPL pathologists. These algorithms and procedures, along with lessons learned from initial implementation of these approaches, guide pathologists at the CPL and CHAMPS sites through standardized diagnostics of MITS cases, and allow for productive, real-time case discussions and consultations.


Roosecelis B Martines, Jana M Ritter, Joy Gary, Wun-Ju Shieh, Jaume Ordi, Martin Hale, Carla Carrilho, Mamudo Ismail, Cheick Boudadari Traore, Benjamin Esiaba Ndibile, Solomon Sava, Farida Arjuman, Mohammed Kamal, Mohammad Mosiur Rahman, Dianna M Blau, Sherif R Zaki the CHAMPS Working Group

OXFORD, Clinical Infectious Diseases, Volume 69, Issue Supplement_4, 15 October 2019, Pages S322–S332