Development and validation of a quantitative point-of-care test for the measurement of severity biomarkers to improve risk stratification of fever syndromes and enhance child survive (EChiLiBRiST) project focuses on improving the diagnosis and treatment of children with fever. The goal is to develop a quick and easy-to-use test that can be used in places like clinics or doctor’s offices to measure specific biomarkers in the blood. These biomarkers, TREM-1 and Ang-2, help determine the severity of a fever. By accurately measuring these markers, healthcare providers can better assess how serious a fever is and decide on the best treatment approach. Improving how we assess and treat fever can significantly reduce child mortality, particularly in areas with limited healthcare resources. The project also involves clinical trials to validate the effectiveness of this new test in real-world settings. Researchers will evaluate how well the test performs in guiding treatment decisions and improving health outcomes for children. Ultimately, the aim is to enhance the way we identify and manage severe fever, leading to better short-term and long-term health outcomes for children.